Radiation dose–response curves: cell repair mechanisms vs. ion track overlapping

Radiation track and DNA damage

Engineering cell-fluorescent ion track hybrid detectors

BACKGROUND The lack of sensitive biocompatible particle track detectors has so far limited parallel detection of physical energy deposition and biological response. Fluorescent nuclear track detectors (FNTDs) based on Al₂O₃:C,Mg single crystals combined with confocal laser scanning microscopy (CLSM) provide 3D information on ion tracks with a resolution limited by light diffraction. Here we rep...

Self-overlapping curves revisited

Let S be a surface embedded in space in such a way that each point has a neighborhood within which the surface is a terrain. Then S projects to an immersed surface in the plane, the boundary of which is a (possibly self-intersecting) curve. Under what circumstances can we reverse these mappings algorithmically? Shor and van Wyk considered one such problem, determining whether a curve is the bou...

Repair-mechanisms and radiation-induced mutations in fission yeast.

UTAGENIC treatments of an adenine-requiring red strain of the fission yeast, Schizosacchtrromyces pombe, lead to the production of two kinds of mutant colonies in which mutation has led to loss of red pigment. One of these is wholly white and these are called complete mutant colonies. The other contains white sectors together with red sectors of the original parental type and these are called m...

Molecular Mechanisms of Ultraviolet Radiation-Induced DNA Damage and Repair

DNA is one of the prime molecules, and its stability is of utmost importance for proper functioning and existence of all living systems. Genotoxic chemicals and radiations exert adverse effects on genome stability. Ultraviolet radiation (UVR) (mainly UV-B: 280-315 nm) is one of the powerful agents that can alter the normal state of life by inducing a variety of mutagenic and cytotoxic DNA lesio...